Anthelmintic Properties of Santonin'
نویسنده
چکیده
In the world of therapeutics certain drugs or preparations have been used for so many years that the statements in the literature, especially in the textbooks and also in articles in professional journals, as to the action of these drugs have a tendency to reiterate impressionistic ideas or traditions. Printed statements are ordinarily copied and passed on with little or no attempt to substantiate the claims made. With a widespread impression once established it is difficult to revise opinions with regard to drugs and a writer is placed in a precarious position if his results conflict with the generally accepted views.
منابع مشابه
Quantification of santonin in eight species of Artemisia from Kazakhstan by means of HPLC-UV: Method development and validation
Santonin, a powerful anthelmintic drug that was formely used to treat worms, is Artemisia cina's main constituent. However, due to its toxicity to humans, it is no longer in use. Kazakhstan is looking to introduce this plant as an anthelmintic drug for veterinary purposes, despite the known toxic properties of the santonin. The objective of this study was to develop a fast and specific method f...
متن کامل[History of the Nippon Shinyaku Institute for Botanical Research].
Soon after its foundation in 1919, Nippon Shinyaku Co., Ltd began to develop the domestic production of Santonin, an anthelmintic agent, which, until then, had been totally imported from Russia. In 1927, Artemisia maritima ssp. monogyna was introduced from Europe and confirmed to contain Santonin. This European aster plant was named Mibu-yomogi after the place name of the headquarters of Nippon...
متن کامل8-[(2-Hydroxyphenyl)imino]-3,5a,9-trimethyl-3a,4,5,5a,8,9b-hexahydronaphtho[1,2-b]furan-2(3H)-one
The title compound, C(21)H(23)NO(3), is a phenyl-imine derivative of the well known anthelmintic agent α-santonin. The trans-fused cyclo-hexane and γ-lactone rings of the α-santonin ring system adopt chair and envelope conformations, respectively, whereas the hexa-diene ring is approximately planar [maximum deviation = 0.029 (4) Å] and forms a dihedral angle of 62.30 (11)° with the benzene ring...
متن کاملIndian Chenopodium
Chenopodium (American wormseed) is one of the most widely-used anthelmintics at the present time. It was used by the American Indians in the days of Columbus, and in South America infusions made from leaves and seeds have been used as a household remedy against intestinal parasites for a long time. Baumler and Fribourg introduced the drug into Europe in 1881 for the treatment of hookworm diseas...
متن کاملMicrobial Transformations of α-Santonin
Fungal biotransformations of α-santonin (1) were conducted with Mucor plumbeus (ATCC 4740), Cunninghamella bainieri (ATCC 9244), Cunninghamella echinulata (ATCC 9245), Curvularia lunata (ATCC 12017) and Rhizopus stolonifer (ATCC 10404). Rhizopus stolonifer (ATCC 10404) metabolized compound 1 to afford 3,4-epoxy-α-santonin (2) and 4,5-dihydroα-santonin (3) while Cunninghamella bainieri (ATCC 924...
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تاریخ انتشار 2010